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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > JaceosidinCAS：18085-97-7
Molecular Formula：C17H14O7
Molecular Weight：330.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 18085-97-7 |
| Name | Jaceosidin |
| Molecular Formula | C17H14O7 |
| Molecular Weight | 330.29 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01081948 |
| SMILES | O=C1C=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C13 |
| Target Point | Bcl-2 Family |
| Passage | Apoptosis |
| Background | Jaceosidin activates Bax and downregulates the expression of Mcl-1 and c-FLIP. |
| Biological Activity | Jaceosidin 是从 Artemisia vestita 中得到的黄酮类化合物，可激活 Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。Jaceosidin 具有抗癌和抗炎作用，能够降低炎性因子水平，激活 NF-κB，抑制 COX-2 的表达。[1-3] |
| Data Literature Source | [1]. Woo SM，et al. Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells. Chem Biol Interact. 2016 Dec 25;260:168-175. [2]. Lee JG，et al. Jaceosidin，isolated from dietary mugwort (Artemisia princeps)，induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation. Food Chem Toxicol. 2013 May;55:214-21. [3]. Min SW，et al. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice. J Ethnopharmacol. 2009 Sep 25;125(3):497-500 |
| Unit | Piece |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Profiling of phenolic acids and flavonoids in sweet potato (Ipomoea batatas L.) leaves and evaluation of their anti-oxidant and hypoglycemic activities
Click to check >>Author：D Luo; Mu T ; Sun H .
IF：4.3050
Publish_to：[J]. Food Bioscience
PMID：
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