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My CartCAS：171228-49-2
Molecular Formula：C37H42F2N8O4
Molecular Weight：700.78
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 171228-49-2 |
| Name | Posaconazole |
| Molecular Formula | C37H42F2N8O4 |
| Molecular Weight | 700.78 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-659-6 |
| MDL | MFCD00941162 |
| SMILES | FC1=CC=C([C@@]2(CN3C=NC=N3)C[C@H](COC4=CC=C(N5CCN(C6=CC=C(N7C=NN([C@@H](CC)[C@H](C)O)C7=O)C=C6)CC5)C=C4)CO2)C(F)=C1 |
| Target Point | Fungal |
| Passage | Anti-infection |
| Background | Posaconazole is a broad-spectrum, second-generation triazole with antifungal activity. |
| Biological Activity | Posaconazole 是一种广谱的，二代三唑类物质，具有抗真菌作用。[1-5] |
| Data Literature Source | [1]. Benaim G，et al. Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. J Med Chem. 2006 Feb 9;49(3):892-9. [2]. Sabatelli F，et al. In vitro activities of posaconazole，fluconazole，itraconazole，voriconazole，and amphotericin B against a large collection of clinically important molds and yeasts. Antimicrob Agents Chemother. 2006 Jun;50(6):2009-15. [3]. Sansone-Parsons A，et al. Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers. Antimicrob Agents Chemother. 2006 May;50(5):1881-3. [4]. Veiga-Santos P，et al. Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi. Int J Antimicrob Agents. 2012 Jul;40(1):61-71. [5]. Sun QN，et al. In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model. Antimicrob Agents Chemother. 2002 Jul;46(7):2310-2. |
| Unit | Piece |
| Specification | 5mg 10mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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