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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Coptisine chlorideCAS：6020-18-4
Molecular Formula：C19H14ClNO4
Molecular Weight：355.77
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 6020-18-4 |
| Name | Coptisine chloride |
| Molecular Formula | C19H14ClNO4 |
| Molecular Weight | 355.77 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 611-948-5 |
| MDL | MFCD00016676 |
| SMILES | C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6.[Cl-] |
| Target Point | Indoleamine 2,3-Dioxygenase (IDO) |
| Passage | Immunology & Inflammation;Metabolic Enzyme&Protease |
| Background | Coptisine chloride is a potent noncompetitive IDO inhibitor. |
| Biological Activity | Coptisine chloride是一种有效的非竞争性IDO抑制剂，Ki值为5.8μM，IC50值为6.3μM[1]。 |
| IC50 | IDO:6.3μM(IC50);IDO:5.8μM(Ki)[1] |
| Data Literature Source | [1]. Yu D，et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. |
| Unit | Piece |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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