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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Combretastatin A4CAS：117048-59-6
Molecular Formula：C18H20O5
Molecular Weight：316.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 117048-59-6 |
| Name | Combretastatin A4 |
| Molecular Formula | C18H20O5 |
| Molecular Weight | 316.35 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD03453309 |
| SMILES | OC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | Combretastatin A4 is a microtubule inhibitor capable of binding to β-tubulin. |
| Biological Activity | Combretastatin A4 是一种 microtubule 抑制剂，能够与 β-tubulin 结合，Kd 值为 0.4 μM[1-4]。 |
| Data Literature Source | [1]. Tochinai R，et al. Combretastatin A4 disodium phosphate-induced myocardial injury. J Toxicol Pathol. 2016 Jul;29(3):163-71. [2]. Signoretto E，et al. Stimulation of Eryptosis by Combretastatin A4 Phosphate Disodium (CA4P). Cell Physiol Biochem. 2016;38(3):969-81 [3]. Zhu J，et al. Co-Encapsulation of Combretastatin-A4 Phosphate and Doxorubicin in Polymersomes for Synergistic Therapy of Nasopharyngeal Epidermal Carcinoma. J Biomed Nanotechnol. 2015 Jun;11(6):997-1006. [4]. Yao N，et al. Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo. Tumour Biol. 2015 Nov;36(11):8499-510. |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Positioning Remodeling Nanogels Mediated Codelivery of Antivascular Drug and Autophagy Inhibitor for Cooperative Tumor Therapy
Click to check >>Author：Zhang H. Ren Y. Hou L. Chang J. Zhang Z. Zhang H
IF：8.7480
Publish_to：ACS Appl Mater Interfaces
PMID：31951366
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