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(+)-Bicuculline

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Cat.No：IB0590 Solarbio

CAS：485-49-4

Molecular Formula：C₂₀H₁₇NO₆

Molecular Weight：367.35

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to yellow Solid

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Product Information

CAS	485-49-4
Name	(+)-Bicuculline
Molecular Formula	C₂₀H₁₇NO₆
Molecular Weight	367.35
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 207-619-7
MDL	MFCD00005006
SMILES	O=C1O[C@@H]([C@H]2N(C)CCC3=C2C=C(OCO4)C4=C3)C5=CC=C(OCO6)C6=C51
InChIKey	IYGYMKDQCDOMRE-ZWKOTPCHSA-N
InChI	InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
PubChem CID	10237
Target Point	GABA Receptor
Passage	Neuronal Signaling;GPCR & G Protein
Background	(+)-Bicuculline is a GABA-A receptor competitive antagonist.
Biological Activity	(+)-Bicuculline (d-Bicuculline)是一种竞争性GABAA受体拮抗剂，IC50为2 μM。除了作为有效的GABAA受体拮抗剂，(+)-Bicuculine也抑制Ca2+激活的钾离子通道。[1-2]
IC50	GABAA receptor:2μM [1]
Data Literature Source	[1] Huang SH，et al. Eur J Pharmacol，2003，464(1)，1-8. [2] Khawaled R，et al. Pflugers Arch，1999，438(3)，314-321.
Unit	Piece
Specification	20mg 10mM*1mL in DMSO 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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