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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > (+)-Usnic AcidCAS：7562-61-0
Molecular Formula：C18H16O7
Molecular Weight：344.32
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 7562-61-0 |
| Name | (+)-Usnic Acid |
| Molecular Formula | C18H16O7 |
| Molecular Weight | 344.32 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 231-456-0 |
| MDL | MFCD00016878 |
| SMILES | O=C([C@@]1(C)C(OC2=C(C(C)=O)C(O)=C(C)C(O)=C12)=C3)C(C(C)=O)C3=O |
| Target Point | Others |
| Passage | Others |
| Background | Binds to the ATP-binding pocket of mTOR and inhibits the activity of mTORC1/2. |
| Biological Activity | (+)-Usnic acid is isolated from isolated from lichens， binds at the ATP-binding pocket of mTOR， and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473)， 4EBP1， S6K， induces autophay， with anti-cancer activity[1]. (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria， including Staphylococcus aureus， Enterococcus faecalis， and Enterococcus faecium[2]. |
| Data Literature Source | [1]. Ebrahim HY，et al. Usnic Acid Benzylidene Analogues as Potent Mechanistic Target of Rapamycin Inhibitors for the Control of Breast Malignancies. J Nat Prod. 2017 Apr 28;80(4):932-952. [2]. Francolini I，et al. Usnic acid，a natural antimicrobial agent able to inhibit bacterial biofilm formation on polymer surfaces. Antimicrob Agents Chemother. 2004;48(11):4360-4365. |
| Unit | Bottle |
| Specification | 20mg 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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