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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Timosaponin A3CAS：41059-79-4
Molecular Formula：C39H64O13
Molecular Weight：740.92
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 41059-79-4 |
| Name | Timosaponin A3 |
| Molecular Formula | C39H64O13 |
| Molecular Weight | 740.92 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01631164 |
| SMILES | C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@H](C)CO4)([H])C[C@@]1([H])[C@@](CC[C@@]5([H])[C@@]6(CC[C@H](O[C@@](O[C@H](CO)[C@H](O)[C@@H]7O)([H])[C@@H]7O[C@]([C@@H]([C@@H](O)[C@@H]8O)O)([H])O[C@@H]8CO)C5)C)([H])[C@]6([H])CC2 |
| Target Point | AChE |
| Passage | Neuronal Signaling |
| Background | Timosaponin AIII inhibits the activity of acetylcholinesterase (AChE). |
| Biological Activity | Timosaponin AIII 能够抑制 乙酰胆碱酯酶 (AChE) 的活性，其 IC50 值为 35.4 μM。[1] |
| IC50 | 35.4μM(AChE)[1]. |
| Data Literature Source | [1]. Lee B，et al. Timosaponin AIII，a saponin isolated from Anemarrhena asphodeloides，ameliorates learning and memory deficits in mice. Pharmacol Biochem Behav. 2009 Aug;93(2):121-7. [2]. King FW，et al. Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PLoS One. 2009 Sep 30;4(9):e7283. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Dong GM, et al. Molecules. 2021 Jun 24;26(13):3861.
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Biotransformation of Timosaponin BII into Seven Characteristic Metabolites by the Gut Microbiota.
Click to check >>Author：Dong GM, Yu H, Pan LB, Ma SR, Xu H, Zhang ZW, Han
IF：4.1480
Publish_to：Molecules.
PMID：34202717
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