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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > TetrandrineCAS：518-34-3
Molecular Formula：C38H42N2O6
Molecular Weight：622.75
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 518-34-3 |
| Name | Tetrandrine |
| Molecular Formula | C38H42N2O6 |
| Molecular Weight | 622.75 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 683-095-7 |
| MDL | MFCD08689909 |
| SMILES | COC1=CC(CCN(C)[C@@]2([H])CC3=CC(O4)=C(OC)C=C3)=C2C(OC5=C(OC)C=C6C([C@]([H])(CC7=CC=C4C=C7)N(C)CC6)=C5)=C1OC |
| Target Point | Calcium Channel |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | Tetrandrine is a bisphenylisoquinoline alkaloid that inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels. |
| Biological Activity | Tetrandrine 是一种双苯基异喹啉生物碱，抑制电压门控钙离子通道 (ICa) 和 Ca2+ 激活的钾离子通道。[1-2] |
| Data Literature Source | [1]. Wang G，et al. Tetrandrine blocks a slow，large-conductance，Ca(2+)-activated potassium channel besides inhibiting a non-inactivating Ca2+ current in isolated nerve terminals of the rat neurohypophysis. Pflugers Arch. 1992 Sep;421(6):558-65. [2]. Zhang Z，et al. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells. J Exp Clin Cancer Res. 2018 Jan 15;37(1):7 |
| Unit | Bottle |
| Specification | 20mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression
Click to check >>Author：Jifen Hu, Jian Gao, Chunlin Wang, Wuling Liu, Anling Hu, Xiao Xiao, Yi Kuang, Kunlin Yu, Babu Gajendran, Eldad Zacksenhaus, Weidong Pan, Yaacov Ben-David
IF：4.6310
Publish_to：Journal of Inflammation Research
PMID：37193069
FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression
Click to check >>Author：Jifen Hu; Jian Gao; Chunlin Wang; Wuling Liu; Anli
IF：4.5000
Publish_to：Journal of Inflammation Research
PMID：37193069
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