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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > ScutellarinCAS：27740-01-8
Molecular Formula：C21H18O12
Molecular Weight：462.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 27740-01-8 |
| Name | Scutellarin |
| Molecular Formula | C21H18O12 |
| Molecular Weight | 462.36 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1806241-263-5 |
| MDL | MFCD01861503 |
| SMILES | O=C(C=C(C1=CC=C(O)C=C1)OC2=CC(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3C(O)=O)=C4O)C2=C4O |
| Target Point | STAT3 |
| Passage | JAK/STAT Signaling |
| Background | It is reported that scutellarin can down-regulate STAT3/Girdin/Akt signal transduction in HCC cells and inhibit RANKL-mediated MAPK and NF in osteoclasts- κ B signal path. |
| Biological Activity | Scutellarin 是从黄芩中分离到的黄酮类物质，在 HCC 细胞中，能够下调 STAT3/Girdin/Akt 信号通路，在破骨细胞中，能够抑制 RANKL 介导的 MAPK/NF-κB 信号通路。[1-5] |
| Data Literature Source | [1]. Ke Y，et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. Biochem Biophys Res Commun. 2016 Dec 18. pii: S0006-291X(16)32174-X [2]. Yang LL，et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. Biochim Biophys Acta. 2016 Nov 27;1863(2):598-606. [3]. Wu CY，et al. Scutellarin attenuates microglia-mediated neuroinflammation and promotes astrogliosis in cerebral ischemia - a therapeutic consideration. Curr Med Chem. 2016 Nov 18. [Epub ahead of print] [4]. Li Q，et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. J Clin Neurosci. 2016 Dec;34:264-270 [5]. Zhao S，et al. Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. Int Immunopharmacol. 2016 Nov;40:458-465 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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