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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Saikosaponin DCAS：20874-52-6
Molecular Formula：C42H68O13
Molecular Weight：780.98
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 20874-52-6 |
| Name | Saikosaponin D |
| Molecular Formula | C42H68O13 |
| Molecular Weight | 780.98 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09028095 |
| SMILES | CC1(C)CC[C@]2(CO3)[C@H](O)C[C@@]4(C)[C@]([C@]5([H])C=C[C@]43[C@]2([H])C1)(C)CC[C@@]([C@]5(C)CC6)([H])[C@@](CO)(C)[C@H]6O[C@@](O[C@H](C)[C@@H]7O)([H])[C@H](O)[C@H]7O[C@@]8([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8 |
| Target Point | SERCA |
| Passage | Membrane Transporter&Ion Channel |
| Background | Saikosaponin D is a triterpenoid saponin from Bupleurum chinense, which has anti-inflammatory, antibacterial, anti-tumor and anti-allergic activities. Saikosaponin D is a new SERCA inhibitor. |
| Biological Activity | Saikosaponin D是一种新型 SERCA 抑制剂，可在凋亡缺陷细胞中诱导自噬性细胞死亡[4] Saikosaponin D 是从柴胡中分离到的三萜皂苷类，具有抗炎，抗菌，抗肿瘤，抗过敏的功效；Saikosaponin D 可以抑制 selectin，STAT3 和 NF-kB 的活性，活化 estrogen receptor-β。[1-3] |
| Data Literature Source | [1]. Jang MJ，et al. Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion. Molecules. 2014 Dec 4;19(12):20340-9. [2]. Liu A，et al. Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. Chem Biol Interact. 2014 Nov 5;223:80-6. [3]. Que R，et al. Estrogen receptor-β-dependent effects of saikosaponind on the suppression of oxidative stress-induced rat hepatic stellate cell activation. Int J Mol Med. 2018 Mar;41(3):1357-1364. [4]. Wong VK，Li T，Law BY，Ma ED，Yip NC，Michelangeli F，Law CK，Zhang MM，Lam KY，Chan PL，Liu L. Saikosaponin-d，a novel SERCA inhibitor，induces autophagic cell death in apoptosis-defective cells. Cell Death Dis. 2013 Jul 11;4(7):e720. |
| Unit | Bottle |
| Specification | 5mg 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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