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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > LiquiritigeninCAS：578-86-9
Molecular Formula：C15H12O4
Molecular Weight：256.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 578-86-9 |
| Name | Liquiritigenin |
| Molecular Formula | C15H12O4 |
| Molecular Weight | 256.25 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00287289 |
| SMILES | O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13 |
| Target Point | Estrogen Receptor |
| Passage | Endocrinology & Hormones |
| Background | Liquiritigenin is a highly selective estrogen receptor beta (ERβ) agonist. |
| Biological Activity | Liquiritigenin是从甘草中分离出的黄烷酮，它是一种高度选择性的雌激素受体β (ERβ) 激动剂，用于活化ERE tk-Luc的 EC50 值为36.5 nM。[1-3] |
| IC50 | EC50: 36.5nM(activation of the ERE tk-Luc)[1] |
| Data Literature Source | [1]. Mersereau JE，et al. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol. 2008 Feb 13;283(1-2):49-57. [2]. Suh KS，et al. Protective effect of liquiritigenin against methylglyoxal cytotoxicity in osteoblastic MC3T3-E1 cells. Food Funct. 2014 Jul 25;5(7):1432-40. [3]. Tao W，et al. Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway. Behav Brain Res. 2016 Jul 15;308:177-86. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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Li X, et al. Heliyon. 2023 Mar 9;9(3)e14353.
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