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Isoimperatorin

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Cat.No：II0370 Solarbio

CAS：482-45-1

Molecular Formula：C₁₆H₁₄O₄

Molecular Weight：270.28

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	482-45-1
Name	Isoimperatorin
Molecular Formula	C₁₆H₁₄O₄
Molecular Weight	270.28
Solubility	Soluble in DMSO ≥10mg/mL
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 801-715-8
MDL	MFCD00272155
SMILES	O=C1C=CC2=C(OC/C=C(C)/C)C3=C(OC=C3)C=C2O1
Target Point	AChE
Passage	Neuronal Signaling
Background	Isoimperatorin can effectively inhibit acetylcholinesterase (AChE).
Biological Activity	Isoimperatorin 是Angelica dahurica 根的甲醇提取物, 有效抑制乙酰胆碱酯酶 (AChE) , IC50 为 74.6 μM[1]。
IC50	IC50: 74.6μM (AChE) [1]
Data Literature Source	[1]. Kim DK， et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec; 25 (6) :856-9. [2]. Liu G， et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23; 21 (10) . pii: E1276. [3]. Park EY， et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8; 11 (7) :e0158796. [4]. Yu XA， et al. The pharmacokinetics， bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14; 10:62.
Unit	Bottle
Specification	10mg 10mM*1mL in DMSO 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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