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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > IsofraxidinCAS：486-21-5
Molecular Formula：C11H10O5
Molecular Weight：222.19
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light brown to brown Solid
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| CAS | 486-21-5 |
| Name | Isofraxidin |
| Molecular Formula | C11H10O5 |
| Molecular Weight | 222.19 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light brown to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00221757 |
| SMILES | O=C1C=CC2=CC(OC)=C(O)C(OC)=C2O1 |
| Target Point | Others |
| Passage | Others |
| Background | Isofraxidin is a coumarin ingredient from Acanthopanax senticosus. |
| Biological Activity | Isofraxidin 来自 Acanthopanax senticosus 的一种香豆素成分，抑制 MMP-7 表达和人肝癌细胞侵袭。Isofraxidin 作用于肝癌细胞，抑制 ERK1/2 磷酸化。Isofraxidin 减弱 iNOS 和 COX-2 表达，Isofraxidin 还抑制 TLR4/髓样分化蛋白 2 (MD-2) 复合物的形成。[1-2] |
| Data Literature Source | [1]. Yamazaki T，et al. Isofraxidin，a coumarin component from Acanthopanax senticosus，inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.Biol Pharm Bull. 2010; 33 (10) :1716-22. [2]. Jin J ，et al. Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development.Food Funct. 2018 Nov 14; 9 (11) :5641-5652. |
| Unit | Bottle |
| Specification | 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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