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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > HispidulinCAS：1447-88-7
Molecular Formula：C16H12O6
Molecular Weight：300.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1447-88-7 |
| Name | Hispidulin |
| Molecular Formula | C16H12O6 |
| Molecular Weight | 300.26 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00143504 |
| SMILES | O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=C(OC)C(O)=C13 |
| Target Point | Pim |
| Passage | JAK/STAT Signaling |
| Background | Hispidulin is an inhibitor of Pim-1. |
| Biological Activity | Hispidulin是具有广泛生物活性的天然黄酮。 Hispidulin是Pim-1的抑制剂，IC50值为2.71 μM[1]。 |
| IC50 | 2.71μM(Pim-1)[1] |
| Data Literature Source | [1]. Chao SW，et al. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene KinasePim-1. J Nat Prod. 2015 Aug 28;78(8):1969-76. [2]. Gao H，et al. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Cell Biochem Biophys. 2014 May;69(1):27-34. [3]. Zhou R，et al. Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway. Cell Biochem Biophys. 2014 Jun;69(2):311-7. [4]. Lin TY，et al. Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats. Eur J Pharmacol. 2015 May 15;755:6-15. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Computational and Experimental Studies Reveal That Thymoquinone Blocks the Entry of Coronaviruses Into In Vitro Cells
Click to check >>Author：Xu H; Liu B; Xiao Z; Zhou M; Ge L; Jia F; Liu Y; J
IF：5.4000
Publish_to：Infectious Diseases and Therapy
PMID：33532909
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