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Hyodeoxycholic acid

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Cat.No：IH0360 Solarbio

CAS：83-49-8

Molecular Formula：C₂₄H₄₀O₄

Molecular Weight：392.57

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	83-49-8
Name	Hyodeoxycholic acid
Molecular Formula	C₂₄H₄₀O₄
Molecular Weight	392.57
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 201-483-2
MDL	MFCD00003681
SMILES	C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Target Point	TGR5 (GPCR19)
Passage	GPCR & G Protein
Background	Hydroxytyrosol is a phenolic compound.
Biological Activity	Hyodeoxycholic acid 是有肠道菌群在小肠中形成的次级胆汁酸，为 TGR5 (GPCR19) 的激动剂，在 CHO 细胞中，EC50 值为 31.6 μM。[1-2]
Data Literature Source	[1]. Sato H， et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening， structure-activity relationships， and molecular modeling studies. J Med Chem. 2008 Mar 27; 51 (6) :1831-41. [2]. Shih DM， et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep; 27 (9) :3805-17.
Unit	Bottle
Specification	50mg 100mg 500mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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