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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > Glycyrrhizic acidCAS：1405-86-3
Molecular Formula：C42H62O16
Molecular Weight：822.95
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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Size：
| CAS | 1405-86-3 |
| Name | Glycyrrhizic acid |
| Molecular Formula | C42H62O16 |
| Molecular Weight | 822.95 |
| Solubility | Soluble in DMSO ≥25mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 258-887-7 |
| MDL | MFCD00065194 |
| SMILES | C[C@]12[C@@](C(C=C3[C@]2(CC[C@]4(C)[C@@]3([H])C[C@](C(O)=O)(C)CC4)C)=O)([H])[C@@]5([C@@](C(C)([C@@H](O[C@]6([H])[C@@H]([C@H]([C@H](O)[C@@H](C(O)=O)O6)O)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O)=O)CC5)C)([H])CC1)C |
| InChIKey | LPLVUJXQOOQHMX-QWBHMCJMSA-N |
| InChI | InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+/m0/s1 |
| PubChem CID | 14982 |
| Target Point | HMGB1 |
| Passage | Others |
| Background | Glycyrrhizic acid， a triterpenoid saponin， is an antagonist of HMGB1， and can be used in studies of tumor and diabetes. |
| Biological Activity | Glycyrrhizic acid 是甘草里面的活性成分三萜皂苷，为 HMGB1 的拮抗剂，具有抗肿瘤、抗糖尿病等功效。[1-3] |
| Data Literature Source | [1]. Su X，et al. Glycyrrhizic acid: A promising carrier material for anticancer therapy. Biomed Pharmacother. 2017 Sep 5;95:670-678 [2]. Wang LY，et al. Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats. Biomed Pharmacother. 2017 Sep 4;95:599-604. [3]. Li C，et al. Glycyrrhizin，a Direct HMGB1 Antagonist，Ameliorates Inflammatory Infiltration in a Model of Autoimmune Thyroiditis via Inhibition of TLR2-HMGB1 Signaling. Thyroid. 2017 May;27(5):722-731. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Gut microbiota-based metabolites of Xiaoyao Pills (a typical Traditional Chinese medicine) ameliorate depression by inhibiting fatty acid amide hydrolase levels in brain
Click to check >>Author：Zheng-Wei Zhang, Pei Han, Jie Fu, Hang Yu, Hui Xu, Jia-Chun Hu, Jin-Yue Lu, Xin-Yu Yang, Hao-Jian Zhang, Meng-Meng Bu, Jian-Dong Jiang, Yan Wang
IF：5.1950
Publish_to：JOURNAL OF ETHNOPHARMACOLOGY
PMID：37100263
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