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Geraniin

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Cat.No：IG0590 Solarbio

CAS：60976-49-0

Molecular Formula：C₄₁H₂₈O₂₇

Molecular Weight：952.65

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	60976-49-0
Name	Geraniin
Molecular Formula	C₄₁H₂₈O₂₇
Molecular Weight	952.65
Solubility	Soluble in DMSO ≥100mg/mL
Purity	HPLC≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD09038731
SMILES	O=C(OC[C@H](O[C@@H](OC(C1=CC(O)=C(O)C(O)=C1)=O)[C@H]2OC3=O)[C@H](OC(C(C4C5=C3C=C(O)C(O)=C5OC6(O)C4(O)O)=CC6=O)=O)[C@H]2O7)C8=CC(O)=C(O)C(O)=C8C9=C(O)C(O)=C(O)C=C9C7=O
Target Point	TNF Receptor
Passage	Apoptosis
Background	Geraniin is a tumor necrosis factor alpha (TNF-alpha) release inhibitor. It has anti-tumor, anti-inflammatory and anti-hyperglycemic activity.
Biological Activity	Geraniin 是具有抗肿瘤、抗炎、抗高血糖活性的、肿瘤坏死因子α (TNF-α) 的释放抑制剂，其 IC50 值为 43 μM。[1-2]
IC50	43μM(TNF-α)[1].
Data Literature Source	[1]. Okabe S，et al. New TNF-alpha releasing inhibitors，geraniin and corilagin，in leaves of Acer nikoense，Megusurino-ki. Biol Pharm Bull. 2001 Oct;24(10):1145-8. [2]. Wang X，et al. Geraniin suppresses ovarian cancer growth through inhibition of NF-κB activation and downregulation of Mcl-1 expression. J Biochem Mol Toxicol. 2017 Sep;31(9).
Unit	Bottle
Specification	5mg 10mg 10mM*1mL in DMSO 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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