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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > FraxinelloneCAS：28808-62-0
Molecular Formula：C14H16O3
Molecular Weight：232.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 28808-62-0 |
| Name | Fraxinellone |
| Molecular Formula | C14H16O3 |
| Molecular Weight | 232.28 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11101451 |
| SMILES | O=C1O[C@@H](C2=COC=C2)[C@]3(C)CCCC(C)=C31 |
| Target Point | Others |
| Passage | Immunology & Inflammation |
| Background | Fraxinellone is a PD-L1 inhibitor. |
| Biological Activity | Fraxinellone 是 PD-L1 抑制剂，可抑制 HIF-1α 蛋白质合成，而不会影响 HIF-1α 蛋白质降解。 Fraxinellone 通过靶向 PD-L1，有可能成为癌症治疗的有价值的候选药物[1]。 |
| Data Literature Source | [1]. Xing Y，et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018 Sep;135:166-180 |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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