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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > ArtesunateCAS：88495-63-0
Molecular Formula：C19H28O8
Molecular Weight：384.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 88495-63-0 |
| Name | Artesunate |
| Molecular Formula | C19H28O8 |
| Molecular Weight | 384.42 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 618-170-5 |
| MDL | MFCD00866204 |
| SMILES | O=C(O[C@H]1[C@H](C)[C@]2([H])CC[C@@H](C)[C@]3([H])CC[C@@](O4)(C)OO[C@]32[C@]4([H])O1)CCC(O)=O |
| InChIKey | FIHJKUPKCHIPAT-AHIGJZGOSA-N |
| InChI | InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1 |
| PubChem CID | 6917864 |
| Target Point | STAT3;EXP1 |
| Passage | JAK/STAT Signaling |
| Background | Artesunate is an inhibitor of STAT-3 and EXP1. |
| Biological Activity | Artesunate 是 STAT-3 和输出蛋白 1 (EXP1) 的抑制剂。[1-3] |
| Data Literature Source | [1]. Ilamathi M，et al. Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma. Curr Top Med Chem. 2016;16(22):2453-63. [2]. Lisewski AM，et al. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell. 2014 Aug 14;158(4):916-928. [3]. Wang B，et al. Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51. Cancer Biol Ther. 2015;16(10):1548-56 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Chen H, et al. Mech Ageing Dev. 2023 Mar;210111760
Wang ZY, et al. Exp Eye Res. 2021 Dec;213108859.
Chen H, et al. Mech Ageing Dev. 2023 Mar;210111760
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Artesunate protects against ocular fibrosis by suppressing fibroblast activation and inducing mitochondria-dependent ferroptosis
Click to check >>Author：Jingyuan Liu, Zheng Pan, Boding Tong, Cong Wang, Jia Yang, Jingling Zou, Jikuan Jiang, Lusi Zhang, Bing Jiang
IF：5.8340
Publish_to：FASEB JOURNAL
PMID：37159329
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response
Click to check >>Author：Chen H. Sun HM. Wu B. Sun TY. Han LZ. Wang G. Shan
IF：5.0130
Publish_to：Mech Ageing Dev
PMID：36476344
Artesunate inhibits the development of PVR by suppressing the TGF-β/Smad signaling pathway
Click to check >>Author：Wang ZY. Zhang Y. Chen J. Wu LD. Chen ML. Chen CM.
IF：3.1610
Publish_to：Exp Eye Res
PMID：34822854
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