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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > AllocryptopineCAS：485-91-6
Molecular Formula：C21H23NO5
Molecular Weight：369.4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 485-91-6 |
| Name | Allocryptopine |
| Molecular Formula | C21H23NO5 |
| Molecular Weight | 369.4 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-626-5 |
| MDL | MFCD00022318 |
| SMILES | O=C1C(C(CCN(C)CC2=C(OC)C(OC)=CC=C2C1)=C3)=CC4=C3OCO4 |
| InChIKey | HYBRYAPKQCZIAE-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H23NO5/c1-22-7-6-14-9-19-20(27-12-26-19)10-15(14)17(23)8-13-4-5-18(24-2)21(25-3)16(13)11-22/h4-5,9-10H,6-8,11-12H2,1-3H3 |
| PubChem CID | 98570 |
| Target Point | Potassium Channel |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is a derivative of tetrahydropalmatine, which can effectively block hERG current. |
| Biological Activity | Allocryptopine， a derivative of tetrahydropalmatine， is extracted from Macleaya cordata (Thunb.) Pers. Papaveraceae. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current[1-2]. |
| Data Literature Source | [1]. Xu B，et al. Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol. Evid Based Complement Alternat Med. 2015;2015:634172. [2]. Lin K，et al. Allocryptopine and benzyltetrahydropalmatine block hERG potassium channels expressed in HEK293 cells. Acta Pharmacol Sin. 2013 Jun;34(6):847-58. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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