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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Mitoxantrone HClCAS：70476-82-3
Molecular Formula：C22H28N4O6·2HCl
Molecular Weight：517.4
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Blue-black Solid
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| CAS | 70476-82-3 |
| Name | Mitoxantrone HCl |
| Molecular Formula | C22H28N4O6·2HCl |
| Molecular Weight | 517.4 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | Blue-black Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 274-619-1 |
| MDL | MFCD00242943 |
| SMILES | O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O.[H]Cl.[H]Cl |
| InChIKey | ZAHQPTJLOCWVPG-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H |
| PubChem CID | 51082 |
| Target Point | Topoisomerase;PKC |
| Passage | DNA Damage/DNA Repair;TGF-beta/Smad;Epigenetics |
| Background | Mitoxantrone HCl is an inhibitor of topoisomerase II; also inhibits protein kinase C (PKC). |
| Biological Activity | Mitoxantrone dihydrochloride是拓扑异构酶II (topoisomerase II)的抑制剂；也可抑制蛋白激酶C (PKC)， IC50值为8.5 μM。[1-4] |
| Data Literature Source | [1]. Takeuchi N，et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7. [2]. Bellosillo B，et al. Mitoxantrone，a topoisomerase II inhibitor，induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6. [3]. Venza I，et al. Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204. [4]. Fujimoto S，et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8(2):157-62 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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