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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > Polyphyllin VIICAS：68124-04-9
Molecular Formula：C51H82O21
Molecular Weight：1031.18
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 68124-04-9 |
| Name | Polyphyllin VII |
| Molecular Formula | C51H82O21 |
| Molecular Weight | 1031.18 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD20260362 |
| SMILES | O[C@@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@@]5(C(C[C@@H](O[C@@]6([H])[C@@H]([C@H]([C@H](O[C@@]7([H])[C@@H]([C@@H]([C@@H](O[C@@]8([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O8)O)O)[C@H](C)O7)O)O)[C@@H](CO)O6)O)O[C@@]9([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O9)O)O)CC5)=CC4)C)([H])CC3)([H])C[C@]1([H])O[C@]%10(CC[C@@H](C)CO%10)[C@H]2C)C |
| InChIKey | FBFJAXUYHGSVFN-IYUYFXHASA-N |
| InChI | InChI=1S/C51H82O21/c1-20-10-15-50(63-19-20)24(5)51(62)31(72-50)17-29-27-9-8-25-16-26(11-13-48(25,6)28(27)12-14-49(29,51)7)67-47-43(71-45-38(59)35(56)33(54)22(3)65-45)40(61)42(30(18-52)68-47)70-46-39(60)36(57)41(23(4)66-46)69-44-37(58)34(55)32(53)21(2)64-44/h8,20-24,26-47,52-62H,9-19H2,1-7H3/t20-,21+,22+,23+,24-,26+,27-,28+,29+,30-,31+,32+,33+,34-,35-,36+,37-,38-,39-,40+,41+,42-,43-,44+,45+,46+,47-,48+,49+,50-,51-/m1/s1 |
| PubChem CID | 176233 |
| Target Point | Others |
| Passage | Others |
| Background | Paris saponin VII is able to attenuate mitochondrial membrane potential, increase the expression of apoptosis-related proteins such as Bax and cytochrome c, and decrease the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt . |
| Biological Activity | Paris saponin VII 诱导的 K562/ADR 细胞凋亡与 Akt/p38 MAPK 和 P-gp 的抑制有关。Paris saponin VII 减弱线粒体膜电位，增加凋亡相关蛋白 (如 Bax 和细胞色素 c) 的表达，并降低 Bcl-2，caspase-9，caspase-3，PARP-1 和 p-Akt 的蛋白表达水平。Paris saponin VII 在 K562/ADR 细胞中诱导强烈的自噬，为白血病治疗提供生化基础。[1-2] |
| Data Literature Source | [1]. Yan T，et al. Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Phytother Res. 2018 May;32(5):898-907. [2]. Li Y，et al. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. J Ethnopharmacol. 2019 Mar 25;232:47-54 |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production
Click to check >>Author：Zhou L. Song H. Zhang Y. Ren Z. Li M. Fu Q
IF：2.2460
Publish_to：BMC Musculoskelet Disord
PMID：32075617
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