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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > CepharanthineCAS：481-49-2
Molecular Formula：C37H38N2O6
Molecular Weight：606.71
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 481-49-2 |
| Name | Cepharanthine |
| Molecular Formula | C37H38N2O6 |
| Molecular Weight | 606.71 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00210482 |
| SMILES | [H][C@]12N(C)CCC(C1=C3)=CC(OC)=C3OC4=C5C(OCO5)=CC6=C4[C@](N(C)CC6)([H])CC(C=C7)=CC=C7OC8=C(OC)C=CC(C2)=C8 |
| InChIKey | YVPXVXANRNDGTA-WDYNHAJCSA-N |
| InChI | InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1 |
| PubChem CID | 10206 |
| Target Point | TNF-α |
| Passage | Apoptosis |
| Background | Cepharanthine is an alkaloid， which can inhibit TNF-α-mediated NFκB stimulation， plasma membrane lipid peroxidation and platelet aggregation， and inhibit the production of cytokines， and has anti-tumor， anti-inflammatory and antioxidant activities. Cepharanthine has been reported to have anti-severe acute respiratory syndrome Coronavirus 2 (anti-SARS-CoV-2) activity. |
| Biological Activity | Cepharanthine is a natural product isolated from the plant Stephania cephalantha Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activity. [1-3] |
| Data Literature Source | [1]. Hijikata A，et al. Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2. FEBS Open Bio. 2022;12(1):285-294 [2]. Li S，Liu W，Chen Y，Wang L，An W，An X，Song L，Tong Y，Fan H，Lu C. Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus. Brief Bioinform. 2021 Mar 22;22(2):1378-1386. [3]. Ohashi H，Watashi K，Saso W，Shionoya K，Iwanami S，Hirokawa T，Shirai T，Kanaya S，Ito Y，Kim KS，Nomura T，Suzuki T，Nishioka K，Ando S，Ejima K，Koizumi Y，Tanaka T，Aoki S，Kuramochi K，Suzuki T，Hashiguchi T，Maenaka K，Matano T，Muramatsu M，Saijo M，Aihara K，Iwami S，Takeda M，McKeating JA，Wakita T. Potential anti-COVID-19 agents，cepharanthine and nelfinavir，and their usage for combination treatment. iScience. 2021 Apr 23;24(4):102367. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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