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Cardamonin

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Cat.No：IC0960 Solarbio

CAS：19309-14-9

Molecular Formula：C₁₆H₁₄O₄

Molecular Weight：270.28

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	19309-14-9
Name	Cardamonin
Molecular Formula	C₁₆H₁₄O₄
Molecular Weight	270.28
Solubility	Soluble in DMSO ≥10mg/mL
Purity	HPLC≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00238554
SMILES	O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2.[E]
InChIKey	NYSZJNUIVUBQMM-BQYQJAHWSA-N
InChI	InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+
PubChem CID	641785
Target Point	TRP Channel;NF-κB
Passage	Membrane Transporter&Ion Channel;Neuronal Signaling;NF-κB
Background	Cardamonin is a hTRPA1 cationic channel antagonist and a NF-kB inhibitor.
Biological Activity	(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.[1-2]
IC50	454nM(hTRPA1 cation channel)[1]
Data Literature Source	[1] Wang S，et al. Molecules. 2016 Aug 29;21(9):pii: E1145. [2] Yuting Li，et al. Cell Death Dis. 2017，8(8): e3024.
Unit	Bottle
Specification	10mg 10mM*1mL in DMSO 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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