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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > CamptothecinCAS：7689/3/4
Molecular Formula：C20H16N2O4
Molecular Weight：348.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 7689/3/4 |
| Name | Camptothecin |
| Molecular Formula | C20H16N2O4 |
| Molecular Weight | 348.35 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 444-280-6 |
| MDL | MFCD00081076 |
| SMILES | O=C1C2=C([C@@](O)(CC)C(OC2)=O)C=C(N1C3)C(C3=C4)=NC5=C4C=CC=C5 |
| InChIKey | VSJKWCGYPAHWDS-FQEVSTJZSA-N |
| InChI | InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1 |
| PubChem CID | 24360 |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | It is a DNA topoisomerase I (Topo I) inhibitor with strong anti-tumor activity. |
| Biological Activity | Campathecin 是有效的 DNA拓扑异构酶 I 抑制剂, IC50 值为 679 nM[1-3]。 |
| IC50 | Topoisomerase I:679nM (IC50) [1-3] |
| Data Literature Source | [1]. Hertzberg RP， et al. Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site. J Biol Chem. 1990 Nov 5; 265 (31) :19287-95. [2]. Hsiang YH， et al. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem. 1985 Nov 25; 260 (27) :14873-8. [3]. Luzzio MJ， et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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