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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > (-)-Huperzine ACAS：102518-79-6
Molecular Formula：C15H18N2O
Molecular Weight：242.32
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 102518-79-6 |
| Name | (-)-Huperzine A |
| Molecular Formula | C15H18N2O |
| Molecular Weight | 242.32 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 600-320-6 |
| MDL | MFCD01714949 |
| SMILES | O=C1NC2=C([C@@](/C3=C\C)(N)CC(C)=C[C@@]3([H])C2)C=C1 |
| InChIKey | ZRJBHWIHUMBLCN-ZUZCIYMTSA-N |
| InChI | InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/t10-,15+/m0/s1 |
| PubChem CID | 449069 |
| Target Point | AChE |
| Passage | Neuronal Signaling |
| Background | HS-1371 is a potent RIP3 kinase inhibitor. |
| Biological Activity | (-)-Huperzine A是从中国草药Huperzia serrata分离出的一种新型的生物碱。(-)-Huperzine A (HupA)是一种有效的，高度特异性的，可逆acetylcholinesterase (AChE)（乙酰胆碱酯酶）抑制剂，Ki为7 nM，作用于G4 AChE比作用于G1 AChE选择性高200倍。(-)-Huperzine A 也是 N-甲基-D-天冬氨酸 (NMDA) 受体的非竞争性拮抗剂。(-)-Huperzine A 被用于神经退行性疾病的研究，包括阿尔茨海默病。[1-4] |
| IC50 | 82nM(AChE) [4] |
| Data Literature Source | [1] Zhao Q，et al. Eur J Pharmacol，2002，455(2-3)，101-107. [2] Zhang HY，et al. Trends Pharmacol Sci，2006，27(12)，619-625. [3] Wang R，et al. Acta Pharmacol Sin，2006，27(1)，1-26. [4]. MA Xiao-Chao，XIN Jian，WANG Hai-Xue，et al. Acute effects of huperzine A and tacrine on rat liver. Acta Pharmacol ogica Sinica，2003，24(3):247-250. [5]. R Wang，et al. Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat. Eur J Pharmacol. 2001 Jun 15;421(3):149-56. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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