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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Z-VAD(OMe)-FMKCAS：187389-52-2
Molecular Formula：C22H30FN3O7
Molecular Weight：467.49
Storage：Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 187389-52-2 |
| Name | Z-VAD(OMe)-FMK |
| Molecular Formula | C22H30FN3O7 |
| Molecular Weight | 467.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00010870 |
| SMILES | O=C(CF)[C@H](CC(OC)=O)NC([C@H](C)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O |
| InChIKey | MIFGOLAMNLSLGH-QOKNQOGYSA-N |
| InChI | InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1 |
| PubChem CID | 5497174 |
| Target Point | Caspase |
| Passage | Apoptosis |
| Background | Z-VAD-FMK is an irreversible pan-caspase inhibitor. Is a ubiquitin C-terminal hydrolase L1 (UCHL1) inhibitor. |
| Biological Activity | Z-VAD(OMe)-FMK 是一种可渗透细胞的不可逆 pan-caspase 抑制剂。Z-VAD（OMe）-FMK是一种广谱半胱天冬酶抑制剂，已被证明可抑制半胱天冬酶样蛋白酶的细胞内活化。[1-3] |
| Data Literature Source | [1]. Kawasaki M，et al. Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspaseinhibitor. Am J Pathol. 2000 Aug;157(2):597-603. [2]. Park S，et al. Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke. 2004 Oct;35(10):2412-7. [3]. Ilangovan R，et al. Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells. J Biol Chem. 2003 Aug 15;278(33):30993-9. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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