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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Z-WEHD-FMKCAS：210344-95-9
Molecular Formula：C30H41FN4O12
Molecular Weight：668.66
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 210344-95-9 |
| Name | Z-WEHD-FMK |
| Molecular Formula | C30H41FN4O12 |
| Molecular Weight | 668.66 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00205201 |
| SMILES | O=C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)[C@H](CCC(OC)=O)NC([C@H](CC(OC)=O)NC(OCC1=CC=CC=C1)=O)=O |
| InChIKey | GBJVAVGBSGRRKN-JYEBCORGSA-N |
| InChI | InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1 |
| PubChem CID | 16760394 |
| Target Point | Caspase |
| Passage | Apoptosis |
| Background | Z-DEVD-FMK is a specific irreversible caspase-3 inhibitor. |
| Biological Activity | Z-DEVD-FMK 是一种特异性的不可逆的 caspase-3 抑制剂, IC50 为 18 μM[1-4]。 |
| IC50 | Caspase-3:18μM (IC50) [1-4] |
| Data Literature Source | [1]. Kanthasamy AG， et al. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radic Biol Med. 2006 Nov 15; 41 (10) :1578-89. [2]. Knoblach SM， et al. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 2004 Oct; 24 (10) :1119-32. [3]. Yakovlev AG， et al. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci. 1997， 17 (19) ， 7415-7424. [4]. Huang MY， et al. Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis. Apoptosis. 2016 Feb; 21 (2) :130-42. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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