{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > AZD3759CAS：1626387-80-1
Molecular Formula：C22H23ClFN5O3
Molecular Weight：459.9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 1626387-80-1 |
| Name | AZD3759 |
| Molecular Formula | C22H23ClFN5O3 |
| Molecular Weight | 459.9 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD29058564 |
| SMILES | ClC1=CC=CC(NC2=NC=NC3=CC(OC)=C(OC(N4[C@H](C)CN(C)CC4)=O)C=C23)=C1F |
| InChIKey | MXDSJQHFFDGFDK-CYBMUJFWSA-N |
| InChI | InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1 |
| PubChem CID | 78209992 |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | AZD3759 is a potent EGFR inhibitor. |
| Biological Activity | Zorifertinib (AZD3759)是一种有效的，具有口服活性的，CNS-渗透性EGFR抑制剂，对EGFR (WT)，EGFR (L858R)，和 EGFR (exon 19Del)的IC50分别为0.3 nM，0.2 nM，和 0.2 nM。[1] |
| Data Literature Source | [1] Zeng Q，et al. J Med Chem. 2015，58(20)，8200-8215. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
