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Anisomycin

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Cat.No：IA0770 Solarbio

CAS：22862-76-6

Molecular Formula：C₁₄H₁₉NO₄

Molecular Weight：265.31

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	22862-76-6
Name	Anisomycin
Molecular Formula	C₁₄H₁₉NO₄
Molecular Weight	265.31
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 245-269-7
MDL	MFCD00077650
SMILES	O[C@@H]1[C@@H](OC(C)=O)[C@@H](CC2=CC=C(OC)C=C2)NC1
InChIKey	YKJYKKNCCRKFSL-RDBSUJKOSA-N
InChI	InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
PubChem CID	253602
Target Point	Bacterial;DNA/RNA Synthesis;JNK
Passage	Anti-infection; Cell Cycle;DNA Damage/DNA Repair;MAPK
Background	It is a bacterial antibiotic and a potent inhibitor of protein synthesis, interfering with protein and DNA synthesis by inhibiting the peptidyl transferase 80 ribosome system. It is also a JNK activator that enhances phosphorylation of JNK.
Biological Activity	Anisomycin是一种有效的蛋白质合成抑制剂，它通过抑制肽基转移酶或80S核糖体系统干扰蛋白质和DNA合成。[1-2]
Data Literature Source	[1]. Lu Z，et al. Colistin-induced autophagy and apoptosis involves the JNK-Bcl2-Bax signaling pathway and JNK-p53-ROS positive feedback loop in PC-12 cells. [2]. Zhao TC，et al. Disruption of Nox2 and TNFRp55/p75 eliminates cardioprotection induced by Anisomycin. Am J Physiol Heart Circ Physiol. 2012 Nov 15;303(10):H1263-72.
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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