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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > CH5183284CAS：1265229-25-1
Molecular Formula：C20H16N6O
Molecular Weight：356.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1265229-25-1 |
| Name | CH5183284 |
| Molecular Formula | C20H16N6O |
| Molecular Weight | 356.38 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| MDL | MFCD28502053 |
| SMILES | O=C(C1=C(N)N(C2=CC=C3N=C(C)NC3=C2)N=C1)C(N4)=CC5=C4C=CC=C5 |
| InChIKey | BEMNJULZEQTDJY-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24) |
| PubChem CID | 66555680 |
| Target Point | FGFR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | CH5183284 is a selective FGFR inhibitor. |
| Biological Activity | CH5183284是选择性的 FGFR 抑制剂，抑制FGFR1，FGFR2和 FGFR3的IC50 值分别为9.3，7.6，22 and 290 nM[1-3]。 |
| IC50 | FGFR1:9.3nM;FGFR2:7.6nM;FGFR3:22nM;FGFR4:290nM [1-3] |
| Data Literature Source | [1]. Nakanishi Y，et al. The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347，a novel selective FGFR inhibitor. Mol Cancer Ther. 2014 Nov;13(11):2547-58. [2]. Nakanishi Y，et al. Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1. Mol Cancer Ther. 2015 Mar;14(3):704-12. [3]. Nakanishi Y，et al. ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347，a Selective FGFR Inhibitor. Mol Cancer Ther. 2015 Dec;14(12):2831-9. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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