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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > HalofuginoneCAS：55837-20-2
Molecular Formula：C16H17BrClN3O3
Molecular Weight：414.68
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 55837-20-2 |
| Name | Halofuginone |
| Molecular Formula | C16H17BrClN3O3 |
| Molecular Weight | 414.68 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 1806241-263-5 |
| MDL | MFCD09834143 |
| SMILES | O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3 |
| InChIKey | LVASCWIMLIKXLA-LSDHHAIUSA-N |
| InChI | InChI=1S/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2/t14-,15+/m0/s1 |
| PubChem CID | 400772 |
| Target Point | prolyl-tRNA synthetase |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | Halofuginone is a competitive prolyl-tRNA synthetase inhibitor. Halofuginone has anti-malarial, anti-inflammatory, anti-cancer and anti-fibrosis activities. |
| Biological Activity | Halofuginone 是 Febrifugine 的一种低毒性衍生物，可从 Dichroa febrifuga 中分离出来[1]。Halofuginone 是一种 ATP 竞争性的脯氨酰-tRNA 合成酶 (prolyl-tRNA synthetase) 抑制剂，Ki 为 18.3 nM[2]。Halofuginone 通过抑制 TGF-β 活性可减轻骨关节炎[3]。 |
| Data Literature Source | [1]. Tsuchida K，et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radic Biol Med. 2017 Feb;103:236-247. [2]. Keller TL，et al. Halofuginone and other Febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7. [3]. Cui Z，et al. Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 2016 Sep;75(9):1714-21. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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