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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > MifepristoneCAS：84371-65-3
Molecular Formula：C29H35NO2
Molecular Weight：429.59
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 84371-65-3 |
| Name | Mifepristone |
| Molecular Formula | C29H35NO2 |
| Molecular Weight | 429.59 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 617-559-7 |
| MDL | MFCD00867226 |
| SMILES | C[C@@]12[C@@](C#CC)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(N(C)C)C=C5)C2)=O |
| InChIKey | VKHAHZOOUSRJNA-GCNJZUOMSA-N |
| InChI | InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1 |
| PubChem CID | 55245 |
| Target Point | Progesterone Receptor; Glucocorticoid Receptor |
| Passage | Endocrinology & Hormones |
| Background | Mifepristone is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist. |
| Biological Activity | Mifepristone是黄体酮受体 (PR) 和糖皮质激素受体 (GR) 拮抗剂，体外实验中的 IC50 值分别为0.2 nM 和2.6 nM。[1-3] |
| Data Literature Source | [1]. Jiang W，et al. New progesterone receptor antagonists: phosphorus-containing 11beta-aryl-substituted steroids. Bioorg Med Chem. 2006 Oct 1;14(19):6726-32. [2]. Jurado R，et al. Cisplatin cytotoxicity is increased by mifepristone in cervical carcinoma: an in vitro and in vivo study. Oncol Rep. 2009 Nov;22(5):1237-45. [3]. Sharrett-Field L，et al. Mifepristone Pretreatment Reduces Ethanol Withdrawal Severity In Vivo. Alcohol Clin Exp Res. 2013 Aug;37(8):1417-23 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Zhang Y, Jin S. Clin Exp Immunol. 2019 Sep;197(3):376-386. doi: 10.1111/cei.13313.
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Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone.
Click to check >>Author：Zhang Y, Jin S.
IF：3.7300
Publish_to：Clin Exp Immunol.
PMID：31091357
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