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(+)-MK 801 Maleate

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Cat.No：IM0300 Solarbio

CAS：77086-22-7

Molecular Formula：C₂₀H₁₉NO₄

Molecular Weight：337.37

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥99%

Appearance：White to off-white Solid

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Product Information

CAS	77086-22-7
Name	(+)-MK 801 Maleate
Molecular Formula	C₂₀H₁₉NO₄
Molecular Weight	337.37
Solubility	Soluble in DMSO
Purity	≥99%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 278-614-5
MDL	MFCD00082465
SMILES	C[C@]12C3=CC=CC=C3C[C@@H](N2)C4=CC=CC=C14.O=C(O)/C=C\C(O)=O
InChIKey	QLTXKCWMEZIHBJ-PJGJYSAQSA-N
InChI	InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1
PubChem CID	6420042
Target Point	iGluR
Passage	Membrane Transporter&Ion Channel
Background	(+)-MK 801 Maleate is a potent, selective, non-competitive NMDA receptor antagonist.
Biological Activity	Dizocilpine maleate (MK-801 maleate) is a potent， selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.[1]
IC50	Ki: 37.2nM(NMDA receptor，in rat brainmembrane)[1]
Data Literature Source	[1]. Wong EH，et al. The anticonvulsant MK-801 is a potent N-Me-D-Asp antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8. [2]. Thomas DM，et al. MK-801 and dextromethorphan block microglial activation and protect against neurotoxicity. Brain Res. 2005 Jul 19;1050(1-2):190-8.
Unit	Bottle
Specification	10mg 10 mM * 1 mL in DMSO 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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