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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > ZileutonCAS：111406-87-2
Molecular Formula：C11H12N2O2S
Molecular Weight：236.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 111406-87-2 |
| Name | Zileuton |
| Molecular Formula | C11H12N2O2S |
| Molecular Weight | 236.29 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 601-087-3 |
| MDL | MFCD00866097 |
| SMILES | CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1 |
| InChIKey | MWLSOWXNZPKENC-UHFFFAOYSA-N |
| InChI | InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) |
| PubChem CID | 60490 |
| Target Point | 5-Lipoxygenase |
| Passage | Metabolic Enzyme&Protease |
| Background | Zileuton is a class of selective 5-lipoxygenase inhibitors. |
| Biological Activity | Zileuton是有效，选择性的5-脂氧合酶抑制剂，具有抗哮喘活性。[1-3] |
| Data Literature Source | [1]. Abueid L， et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10 [2]. Kuvibidila S， et al. Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease. Ochsner [3]. Gounaris E， et al. Zileuton， 5-lipoxygenase inhibitor， acts as a chemopreventive agent in intestinal polyposis， by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6; 10 (3) :e0121402 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Network pharmacology identification of mechanisms of cerebral ischemia injury amelioration by Baicalin and Geniposide
Click to check >>Author：Wu J. Wang B. Li M. Shi YH. Wang C. Kang YG
IF：4.1200
Publish_to：Eur J Pharmacol
PMID：31229537
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