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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > VorinostatCAS：149647-78-9
Molecular Formula：C14H20N2O3
Molecular Weight：264.32
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 149647-78-9 |
| Name | Vorinostat |
| Molecular Formula | C14H20N2O3 |
| Molecular Weight | 264.32 |
| Solubility | Soluble in DMSO ≥30mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 682-505-1 |
| MDL | MFCD00945317 |
| SMILES | O=C(NC1=CC=CC=C1)CCCCCCC(NO)=O |
| InChIKey | WAEXFXRVDQXREF-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) |
| PubChem CID | 5311 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Vorinostat is a potent HDAC inhibitor. Vorinostat can induce apoptosis. Vorinostat is also a potent inhibitor of human papillomavirus (HPV)-18 DNA amplification. |
| Biological Activity | Vorinostat 是一种有效的，可口服的 HDAC1，HDAC2，HDAC3 (Class I)，HDAC7 (Class II) 和 Class IV (HDAC11) 的抑制剂，对 HDAC1/3 的 ID50 值分别为 10 nM 和 20 nM。[1-6] |
| Data Literature Source | [1]. Hrzenjak A et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer. 2010 Mar 4;9:49. [2]. Lautz TB，et al. The effect of vorinostat on the development of resistance to Doxorubicin in neuroblastoma.PLoS One. 2012;7(7):e40816. [3]. Richon VM，et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7. [4]. Xu WS，et al. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene. 2007 Aug 13;26(37):5541-52. [5]. Pérez-Ca amás A，et al. Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease. Mol Psychiatry. 2017 May;22(5):711-723. [6]. Wang J，et al. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1. Nat Commun. 2017 Dec 20;8(1):2207. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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