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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > VinblastineCAS：865-21-4
Molecular Formula：C46H58N4O9
Molecular Weight：810.97
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 865-21-4 |
| Name | Vinblastine |
| Molecular Formula | C46H58N4O9 |
| Molecular Weight | 810.97 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 212-734-0 |
| MDL | MFCD05662370 |
| SMILES | CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O |
| InChIKey | JXLYSJRDGCGARV-CFWMRBGOSA-N |
| InChI | InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6，36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2，37(44)50)39(59-27(3)51)46(38，55)41(53)58-7/h10-14，16，21-22，28，37-39，47，54-55H，8-9，15，17-20，23-26H2，1-7H3/t28-，37-，38+，39+，42-，43+，44+，45-，46-/m0/s1 |
| PubChem CID | 13342 |
| Target Point | Microtubule/Tubulin;nAChR |
| Passage | Cytoskeleton;Neuronal Signaling;Membrane Transporter&Ion Channel |
| Background | Vinblastine inhibited microtubule formation and nAChR activity. |
| Biological Activity | Vinblastine是一种针对各种癌症类型的有细胞毒性的生物碱。 长春花碱可抑制微管的形成，抑制nAChR的IC50值为8.9 μM。[1-5] |
| Data Literature Source | [1]. McKay DB，et al. Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993 Jul; 203 (3) :372-6. [2]. Pandya P，et al. Molecular recognition pattern of cytotoxic alkaloid vinblastine with multiple targets. J Mol Graph Model. 2014 Nov; 54:1-9. [3]. Calvi o E，et al. JNK and NFκB dependence of apoptosis induced by vinblastine in human acute promyelocytic leukaemia cells. Cell Biochem Funct. 2015 Jun; 33 (4) :211-9. [4]. Selimovic D，et al. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis. 2013 Aug; 18 (8) :980-97. [5]. Bánóczi Z，et al. Synthesis and in vitro antitumor effect of vinblastine derivative-oligoarginine conjugates. Bioconjug Chem. 2010 Nov 17; 21 (11) :1948-55. |
| Unit | Bottle |
| Specification | 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Efficacy and cardiotoxicity integrated assessment of anticancer drugs by a dual functional cell-based biosensor
Click to check >>Author：Xinwei Wei; Gu C ; Li H ;et al
IF：8.4000
Publish_to：Sensors and Actuators B: Chemical
PMID：
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