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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > TelmisartanCAS：144701-48-4
Molecular Formula：C33H30N4O2
Molecular Weight：514.62
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 144701-48-4 |
| Name | Telmisartan |
| Molecular Formula | C33H30N4O2 |
| Molecular Weight | 514.62 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 620-494-7 |
| MDL | MFCD00918125 |
| SMILES | O=C(C1=CC=CC=C1C2=CC=C(CN3C4=CC(C5=NC6=CC=CC=C6N5C)=CC(C)=C4N=C3CCC)C=C2)O |
| InChIKey | RMMXLENWKUUMAY-UHFFFAOYSA-N |
| InChI | InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39) |
| PubChem CID | 65999 |
| Target Point | Angiotensin Receptor |
| Passage | GPCR & G Protein |
| Background | Telmisartan is a potent angiotensin II type 1 receptor antagonist. |
| Biological Activity | Telmisartan 是一种有效的血管紧张素II 1型受体 (angiotensin II type 1 receptor) 拮抗剂, 能够抑制其活性, IC50 值为 9.2 nM[1]。 |
| IC50 | IC50: 9.2nM (angiotensin II type 1 receptor) [1] |
| Data Literature Source | [1]. Maillard MP， et al. In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist. J Pharmacol Exp Ther. 2002 Sep; 302 (3) :1089-95. [2]. Xuan H， et al. Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms. J Vasc Surg. 2017 Apr 20. pii: S0741-5214 (17) 30100-3. [3]. Torika N， et al. Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer's disease mice. Brain Behav Immun. 2017 Apr 3. [4]. Aswar U， et al. Telmisartan attenuates diabetes induced depression in rats. Pharmacol Rep. 2017 Apr; 69 (2) :358-364. [5]. Fujihara S， et al. The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo. Oncotarget. 2017 Jan 31; 8 (5) :8536-8549 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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