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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > TacrolimusCAS：104987-11-3
Molecular Formula：C44H69NO12
Molecular Weight：804.02
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 104987-11-3 |
| Name | Tacrolimus |
| Molecular Formula | C44H69NO12 |
| Molecular Weight | 804.02 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1308068-626-2 |
| MDL | MFCD00869853 |
| SMILES | O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O |
| InChIKey | QJJXYPPXXYFBGM-LFZNUXCKSA-N |
| InChI | InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1 |
| PubChem CID | 445643 |
| Target Point | Phosphatase |
| Passage | Metabolic Enzyme&Protease |
| Background | Tacrolimus is an antibiotic and a powerful new immunosuppressant. It mainly inhibits the release of IL-2 and the function of T lymphocytes, and can combine with FKBP to form a complex and inhibit the activity of calcineurin. |
| Biological Activity | Tacrolimus是一种具有强效免疫抑制特性的大环内酯。 他克莫司与FK506结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶 (calcineurin phosphatase)。[1-5] |
| Data Literature Source | [1]. Thomson AW，et al. Mode of action of Tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91. [2]. Vogel KR，et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD)，a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39(6):877-886. [3]. Zhu H，et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo. Mol Med Rep. 2014 Aug;10(2):585-92. [4]. Okada Y，et al. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interferon-γ and interleukin-1β suppression. Biol Pharm Bull. 2011;34(12):1823-7. [5]. Yuwei He，et al. Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis. Nano Res. 30 June 2018. |
| Unit | Bottle |
| Specification | 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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