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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > StreptozocinCAS：18883-66-4
Molecular Formula：C8H15N3O7
Molecular Weight：265.22
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 18883-66-4 |
| Name | Streptozocin |
| Molecular Formula | C8H15N3O7 |
| Molecular Weight | 265.22 |
| Solubility | Soluble in Water/DMSO/Sodium Citrate buffer(0.1mol/L, pH4.5, sterile)（The product is unstable after dissolution. It is recommended that you use it immediately after dissolution.） |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 242-646-8 |
| MDL | MFCD00006607 |
| SMILES | O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](NC(N(C)N=O)=O)[C@H]1O |
| InChIKey | ZSJLQEPLLKMAKR-GKHCUFPYSA-N |
| InChI | InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1 |
| PubChem CID | 29327 |
| Target Point | DNA Methylation |
| Passage | Epigenetics |
| Background | Streptozocin is a potent DNA methylation agent. STZ can increase the blood sugar of mice, and is a commonly used inducer of diabetes modeling. Meanwhile, the diabetic effect of STZ is different in species. This product is unstable, it is recommended to use now.） |
| Biological Activity | Streptozocin是一种有效的 DNA甲基化试剂，在HL60，K562和C1498细胞中的IC50 分别为11.7，904 和 1024 μg/mL。还是一种糖尿病诱导剂，可诱导自噬与凋亡。[1-3] |
| Data Literature Source | [1]. Bennett RA， et al. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul; 41 (7) :2786-90 [2]. Diab RA， et al. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb; 163 (2) :193-8 [3]. Acer S， et al. Oxidative stress of crystalline lens in rat menopausal model. Arq Bras Oftalmol. 2016 Jul-Aug; 79 (4) :222-5 |
| Unit | Bottle |
| Specification | 10mg 20mg 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Zhong QW, et al. Food Chem. 2021 Mar 30;341(Pt 1):128148.
Zhen D, et al. Heliyon. 2023 Jun 27;9(7):e17733.
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STZ可以配制母液长期保存吗？具体的母液配制方法如何？ 2023-10-07 13:23:18
Administrator母液保存在-20℃, 有效期1个月。配置好的母液建议按照实验需要分装冻存，避免反复冻融。