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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > SorafenibCAS：284461-73-0
Molecular Formula：C21H16ClF3N4O3
Molecular Weight：464.83
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 284461-73-0 |
| Name | Sorafenib |
| Molecular Formula | C21H16ClF3N4O3 |
| Molecular Weight | 464.83 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 608-209-4 |
| MDL | MFCD06411450 |
| SMILES | O=C(NC(C=C1)=CC=C1OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3 |
| InChIKey | MLDQJTXFUGDVEO-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) |
| PubChem CID | 216239 |
| Target Point | Ferroptosis;Raf |
| Passage | Apoptosis;MAPK |
| Background | It is a potent Raf inhibitor and a multi-kinase inhibitor, which has inhibitory effect on VEGFR2,VEGFR3,PDGFRβ,FLT3 and c-Kit. It was also a ferroptosis agonist that induced autophagy and apoptosis. |
| Biological Activity | Sorafenib (Bay 43-9006) 是有效的多激酶抑制剂，抑制Raf-1，B-Raf 和 VEGFR-3 的 IC50 分别为6 nM，20 nM，22 nM。[1-4] |
| Data Literature Source | [1]. Wilhelm SM，et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109. [2]. El-Ashmawy NE，et al. Sorafenib effect on liver neoplastic changes in rats: more than a kinase inhibitor. Clin Exp Med. 2016 Apr 16. [3]. Jin W，et al. Long non-coding RNA TUC338 is functionally involved in sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1. Oncol Rep. 2017 Jan;37(1):273-280. [4]. Li M，et al. Activation of an AKT/FOXM1/STMN1 pathway drives resistance to tyrosine kinase inhibitors in lung cancer. Br J Cancer. 2017 Aug 29. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Li B, et al. Front Oncol. 2021 Aug 16;11:657723.
Li B, et al. Front Oncol. 2021 Aug 16;11:657723.
Li B, et al. Front Oncol. 2021 Aug 16;11:657723.
Li B, et al. Front Oncol. 2021 Aug 16;11:657723.
Wang Z, et al. Cell Rep Med. 2023 Apr 18;4(4):101014.
Wang Z, et al. Cell Rep Med. 2023 Apr 18;4(4):101014.
Pan Y, et al. Biosens Bioelectron. 2019 Apr 1;130:344-351.
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Self-adaptive nanoassembly enabling turn-on hypoxia illumination and periphery/center closed-loop tumor eradication
Click to check >>Author：Ziyue Wang, Shenwu Zhang, Zhiqiang Kong, Songhao Li, Jin Sun, Ying Zheng, Zhonggui He, Hao Ye, Cong Luo
IF：16.9880
Publish_to：Cell Reports Medicine
PMID：37075700
Self-adaptive nanoassembly enabling turn-on hypoxia illumination and periphery/center closed-loop tumor eradication
Click to check >>Author：Wang Z; Zhang S; Kong Z; Li S; Sun J; Zheng Y; He
IF：14.3000
Publish_to：Cell Rep Med
PMID：37075700
3D cell-based biosensor for cell viability and drug assessment by 3D electric cell/matrigel-substrate impedance sensing.
Click to check >>Author：Pan Y, Hu N, Wei X, Gong L, Zhang B, Wan H, Wang P
IF：9.5180
Publish_to：Biosens Bioelectron.
PMID：30266425
CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma
Click to check >>Author：Li B; Wei S; Yang L; Peng X; Ma Y; Wu B; Fan Q; Ya
IF：4.7000
Publish_to：Front Oncol
PMID：34485112
Dietary antioxidant quercetin overcomes the acquired resistance of Sorafenib in Sorafenib-resistant hepatocellular carcinoma cells through epidermal growth factor receptor signaling inactivation
Click to check >>Author：Zhang Zhengguang, Wu Haitao, Zhang Yajie, Shen Cunsi, Zhou Fuqiong
IF：3.6000
Publish_to：NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
PMID：37490119
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