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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > SitagliptinCAS：486460-32-6
Molecular Formula：C16H15F6N5O
Molecular Weight：407.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 486460-32-6 |
| Name | Sitagliptin |
| Molecular Formula | C16H15F6N5O |
| Molecular Weight | 407.31 |
| Solubility | Soluble in Water ≥10mg/mL;Soluble in DMSO ≥25mg/mL(Need ultrasound or water bath) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 690-730-1 |
| MDL | MFCD19684081 |
| SMILES | O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F |
| InChIKey | MFFMDFFZMYYVKS-SECBINFHSA-N |
| InChI | InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1 |
| PubChem CID | 4369359 |
| Target Point | Dipeptidyl Peptidase (DPP) |
| Passage | Metabolic Enzyme&Protease |
| Background | Sitagliptin is a potent DPP4 inhibitor |
| Biological Activity | Sitagliptin 是一种有效的 DPP4 抑制剂，在 Caco-2 细胞中，IC50 值为 19 nM。[1-5] |
| Data Literature Source | [1]. Thomas，L.，et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3，7-dihydro-purine-2，6-dione (BI 1356)，a novel xanthine-based dipeptidyl peptidase 4 inhibitor，has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther. 2008 Apr;325(1):175-82. [2]. Kim，S.J.，et al.，Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes，2009. 58(3): p. 641-51. [3]. Sangle，G.V.，et al.，Novel biological action of the dipeptidylpeptidase-IV inhibitor，sitagliptin，as a glucagon-like peptide-1 secretagogue. Endocrinology，2012. 153(2): p. 564-73. [4]. Kim，S.J.，et al.，Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes，2008. 57(5): p. 1331-9. [5]. Beconi，M.G.，et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metab Dispos，2007. 35(4): p. 525-32. |
| Unit | Bottle |
| Specification | 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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