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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > SimvastatinCAS：79902-63-9
Molecular Formula：C25H38O5
Molecular Weight：418.57
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 79902-63-9 |
| Name | Simvastatin |
| Molecular Formula | C25H38O5 |
| Molecular Weight | 418.57 |
| Solubility | Soluble in DMSO/Ethanol ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 404-520-2 |
| MDL | MFCD00072007 |
| SMILES | CCC(C)(C)C(O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O |
| InChIKey | RYMZZMVNJRMUDD-HGQWONQESA-N |
| InChI | InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 |
| PubChem CID | 54454 |
| Target Point | HMG-CoA Reductase (HMGCR) |
| Passage | Metabolic Enzyme&Protease |
| Background | Simvastatin is a competitive HMG-CoA reductase inhibitor. |
| Biological Activity | Simvastatin 是一种竞争性的 HMG-CoA reductase 抑制剂, Ki 值为 0.2 nM[1]。 |
| IC50 | Ki: 0.2nM (HMG-CoA reductase) [1] |
| Data Literature Source | [1]. Slater， E.E.， et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs， 1988. 36 Suppl 3: p. 72-82. [2]. Kureishi， Y.， et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med， 2000. 6 (9) : p. 1004-10. [3]. Leung BP， et al. A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol. 2003 Feb 1; 170 (3) :1524-30. [4]. Kobayashi M， et al. Preventive effect of MK-733 (simvastatin) ， an inhibitor of HMG-CoA reductase， on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits. Jpn J Pharmacol. 1989 Jan; 49 (1) :125-33. [5]. Ishida F， et al. Comparative effects of simvastatin (MK-733) and pravastatin (CS-514) on hypercholesterolemia induced by cholesterol feeding in rabbits. Biochim Biophys Acta. 1990 Feb 23; 1042 (3) :365-73. [6]. Sukhova GK， et al. Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol. 2002 Sep 1; 22 (9) :1452-8. [7]. Weijiang Dong， et al. Differential effects of simvastatin and pravastatin on expression of Alzheimer’s disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct; 50 (10) : 2095-2102. [8]. Liu Z， et al. Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat. Oxid Med Cell Longev. 2017; 2017:3861914 |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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