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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > SildenafilCAS：139755-83-2
Molecular Formula：C22H30N6O4S
Molecular Weight：474.58
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 139755-83-2 |
| Name | Sildenafil |
| Molecular Formula | C22H30N6O4S |
| Molecular Weight | 474.58 |
| Solubility | Soluble in DMSO ≥30mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-659-6 |
| MDL | MFCD00867528 |
| SMILES | O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(C)CC4)=O)=CC=C3OCC)N1 |
| InChIKey | BNRNXUUZRGQAQC-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) |
| PubChem CID | 135398744 |
| Target Point | Phosphodiesterase (PDE) |
| Passage | Metabolic Enzyme&Protease |
| Background | Sildenafil is a phosphodiesterase 5 (PDE-5) inhibitor |
| Biological Activity | Sildenafil是磷酸二酯酶5 (PDE-5) 抑制剂, IC50为5.22 nM, 可能是最好的可作用于勃起功能紊乱的化合物[1]。 |
| IC50 | IC50: 5.22nM (PDE 5) [1] |
| Data Literature Source | [1]. Wang Z， et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov; 10 (11) :2790-7. [2]. Li BB， et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl) . 2011 Sep; 124 (17) :2733-40. [3]. Moretti R， et al. Sildenafil， a cyclic GMP phosphodiesterase inhibitor， induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28; 13 (1) :95. [4]. Korkmaz MF， et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar; 33 (2) :204-11. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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