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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > Schisantherin ACAS：58546-56-8
Molecular Formula：C30H32O9
Molecular Weight：536.57
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 58546-56-8 |
| Name | Schisantherin A |
| Molecular Formula | C30H32O9 |
| Molecular Weight | 536.57 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09026937 |
| SMILES | O[C@]([C@@H](C)C1)(C)[C@@H](OC(C2=CC=CC=C2)=O)C3=CC(OC)=C(OC)C(OC)=C3C4=C1C=C5OCOC5=C4OC |
| InChIKey | UFCGDBKFOKKVAC-DSASHONVSA-N |
| InChI | InChI=1S/C30H32O9/c1-16-12-18-13-21-25(38-15-37-21)26(35-5)22(18)23-19(14-20(33-3)24(34-4)27(23)36-6)28(30(16,2)32)39-29(31)17-10-8-7-9-11-17/h7-11,13-14,16,28,32H,12,15H2,1-6H3/t16-,28-,30-/m0/s1 |
| PubChem CID | 151529 |
| Target Point | Orexin Receptor (OX Receptor) |
| Passage | NF-κB |
| Background | Schisantherin A inhibits the translocation of p65-NF-κB into the nucleus by degradation of IκBα. |
| Biological Activity | Schisantherin A 是从 Schisandra sphenanthera 果实中分离出来的一种木脂素。Schisantherin A 通过 IκBα 降解来抑制 p65-NF-κB 易位进入细胞核。[1-2] |
| Data Literature Source | [1]. Ci X， et al. Schisantherin A exhibits anti-inflammatory properties by down-regulating NF-kappaB and MAPK signaling pathways in lipopolysaccharide-treated RAW 264.7 cells. Inflammation. 2010 Apr; 33 (2) :126-36. [2]. Zhou E， et al. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Int Immunopharmacol. 2014 Sep; 22 (1) :133-40. |
| Unit | Bottle |
| Specification | 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Changes in phytochemical compositions and antioxidant activity of Schisandra sphenathera fruit during ripening
Click to check >>Author：Bohan Ma, Xinghua Zhao, Bin Dai, Mengge Zhao, Xingbin Yang, Langjun Cui, Hongjun Shao
IF：6.4490
Publish_to：INDUSTRIAL CROPS AND PRODUCTS
PMID：
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