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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Sanguinarine ChlorideCAS：5578-73-4
Molecular Formula：C20H14NO4Cl
Molecular Weight：367.78
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Orange to red Solid
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| CAS | 5578-73-4 |
| Name | Sanguinarine Chloride |
| Molecular Formula | C20H14NO4Cl |
| Molecular Weight | 367.78 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Orange to red Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00003004 |
| SMILES | C[N+]1=CC2=C3C(OCO3)=CC=C2C(C=CC4=C5)=C1C4=CC6=C5OCO6.[Cl-] |
| InChIKey | GIZKAXHWLRYMLE-UHFFFAOYSA-M |
| InChI | InChI=1S/C20H14NO4.ClH/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21;/h2-8H,9-10H2,1H3;1H/q+1;/p-1 |
| PubChem CID | 68635 |
| Target Point | Apoptosis |
| Passage | Apoptosis |
| Background | Sanguinarine Chloride is an alkaloid that stimulates apoptosis by activating the production of reactive oxygen species (ROS). The induced apoptosis is associated with the activation of JNK and NF-κB. |
| Biological Activity | Sanguinarine chloride 是一种来源于 Sanguinaria Canadensis 的生物碱，可通过激活活性氧 (ROS) 的产生来刺激细胞凋亡。Sanguinarine 诱导的细胞凋亡与 JNK 和 NF-κB 的活化有关。[1] |
| Data Literature Source | [1]. Wang Y，Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species. Oncotarget. 2016 Apr 19;7(16):22355-68. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Alfhili MA, et al. Toxicon. 2021 Aug;199:41-48. doi: 10.1016/j.toxicon.2021.05.013.
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Epidemic dropsy toxin, sanguinarine chloride, stimulates sucrose-sensitive hemolysis and breakdown of membrane phospholipid asymmetry in human erythrocytes.
Click to check >>Author：Alfhili MA, Alsughayyir J, Basudan AB.
IF：3.0330
Publish_to：Toxicon.
PMID：34081931
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