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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Rosmarinic acidCAS：20283-92-5
Molecular Formula：C18H16O8
Molecular Weight：360.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 20283-92-5 |
| Name | Rosmarinic acid |
| Molecular Formula | C18H16O8 |
| Molecular Weight | 360.31 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 606-487-1 |
| MDL | MFCD00017740 |
| SMILES | OC([C@H](OC(/C=C/C1=CC(O)=C(O)C=C1)=O)CC2=CC(O)=C(O)C=C2)=O |
| InChIKey | DOUMFZQKYFQNTF-WUTVXBCWSA-N |
| InChI | InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1 |
| PubChem CID | 5281792 |
| Target Point | MAO(Monoamine Oxidase) |
| Passage | Neuronal Signaling |
| Background | Rosmarinic acid can inhibit MAO-A, MAO-B, and COMT, exhibiting strong antioxidant and anti-inflammatory activities, as well as antibacterial, antiviral, and anti-tumor activities. |
| Biological Activity | 迷迭香酸 (Rosmarinic acid) 是一种天然多酚物质，具有抗氧化、抗炎活性。[1-3] |
| IC50 | 50.1μM(MAO-A)，184.6μM(MAO-B)，26.7μM(COMT)[1] |
| Data Literature Source | [1]. Andrade JM，et al. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45. [2]. Fernando PM，et al. Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells. Biomol Ther (Seoul). 2016 Jan;24(1):75-84. [3]. Jin BR，et al. Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation. Sci Rep. 2017 Apr 6;7:46252. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Effects of gene silencing of indoleamine 2,3-dioxygenase 1 combined with rosmarinic acid on tumor immune microenvironment in H22 tumor-bearing mice
Click to check >>Author：Wen Cao, Jinfeng Pan, Kai Mo, Zhenning Wang, Sijun Wei, Yuan Yin, Mengyao Qin, Wenjuan Zhang
IF：5.7140
Publish_to：INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：37062258
Rosmarinic Acid as a Candidate in a Phenotypic Profiling Cardio-/Cytotoxicity Cell Model Induced by Doxorubicin
Click to check >>Author：Zhang Q. Li J. Peng S. Zhang Y. Qiao Y
IF：4.1840
Publish_to：Molecules
PMID：32075047
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