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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > RosiglitazoneCAS：122320-73-4
Molecular Formula：C18H19N3O3S
Molecular Weight：357.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 122320-73-4 |
| Name | Rosiglitazone |
| Molecular Formula | C18H19N3O3S |
| Molecular Weight | 357.43 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 924-121-1 |
| MDL | MFCD00871760 |
| SMILES | O=C(N1)SC(CC2=CC=C(OCCN(C)C3=NC=CC=C3)C=C2)C1=O |
| InChIKey | YASAKCUCGLMORW-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23) |
| PubChem CID | 77999 |
| Target Point | PPAR;TRP Channe |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease;Membrane Transporter/Ion Channel |
| Background | Rosiglitazone is an effective PPAR γ Selective agonists. Rosiglitazone is a TRPC5 activator and TRPM3 inhibitor. Rosiglitazone can be used for research on obesity, diabetes, aging and ovarian cancer. |
| Biological Activity | Rosiglitazone (BRL49653) 是一种有效的噻唑烷二酮胰岛素增敏剂。 Rosiglitazone是一种选择性的PPARγ 激动剂，对 PPARγ1，PPARγ2 和 PPARγ 的EC50 分别为 30 nM，100 nM 和 60 nM。[1-5] |
| IC50 | PPARγ1:30nM(EC50);PPARγ2:100nM(EC50)[1-5] |
| Data Literature Source | [1]. Lehmann JM，et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem. 1995 Jun 2;270(22):12953-6. [2]. Willson TM，et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996 Feb 2;39(3):665-8. [3]. Thouennon E，et al. Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection. J Neurochem. 2015 Aug;134(3):463-70. [4]. Majeed Y，et al. Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels. Mol Pharmacol. 2011 Jun;79(6):1023-30. [5]. Ateyya H，et al. Beneficial effects of rosiglitazone and losartan combination in diabetic rats. Can J Physiol Pharmacol. 2018 Mar;96(3):215-220 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression
Click to check >>Author：LiL;FuJ;LiuD;SunJ;HouY;ChenC;ShaoJ;WangL;WangX;Zha
IF：10.4670
Publish_to：Redox Biol
PMID：31901728
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