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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > RapamycinCAS：53123-88-9
Molecular Formula：C51H79NO13
Molecular Weight：914.18
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 53123-88-9 |
| Name | Rapamycin |
| Molecular Formula | C51H79NO13 |
| Molecular Weight | 914.18 |
| Solubility | Soluble in DMSO ≥10mg/mL；Soluble in Ethanol ≥2mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 262-640-9 |
| MDL | MFCD00867594 |
| SMILES | O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](O)CC4)OC)C)=O)=O |
| InChIKey | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
| InChI | InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1 |
| PubChem CID | 5284616 |
| Target Point | mTOR;Autophagy |
| Passage | PI3K/Akt/mTOR;Autophagy |
| Background | Rapamycin is a macrolide immunosuppressive agent, as well as an effective and specific mTOR inhibitor and autophagy activator. |
| Biological Activity | Rapamycin (Sirolimus) 是一种特异性的 mTOR 抑制剂，IC50 为 0.1 nM。[1-5] |
| Data Literature Source | [1]. Edwards SR，et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem，2007，282(18)，13395-13401. [2]. Lalic H，et al. Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells. Leuk Lymphoma. 2012 Nov;53(11):2253-61. [3]. Takeuchi H，et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res，2005，65(8)，3336-3346. [4]. Bodine SC，et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol，2001，3(11)，1014-1019. [5]. Marin TM，et al. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associatedPTPN11 mutation. J Clin Invest. 2011 Mar;121(3):1026-43. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Li C, et al. Arch Pharm Res. 2020 Aug;43(8):863-874.
Li C, et al. Arch Pharm Res. 2020 Aug;43(8):863-874.
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