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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > QuercetinCAS：117-39-5
Molecular Formula：C15H10O7
Molecular Weight：302.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 117-39-5 |
| Name | Quercetin |
| Molecular Formula | C15H10O7 |
| Molecular Weight | 302.24 |
| Solubility | Soluble in DMSO ≥10mg/mL;Soluble in Ethanol ≥5mg/mL;Soluble in Water ＜1mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 204-187-1 |
| MDL | MFCD00006828 |
| SMILES | OC1=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1=O |
| InChIKey | REFJWTPEDVJJIY-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H |
| PubChem CID | 5280343 |
| Target Point | Sirtuin;PI3K |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics;PI3K/Akt/mTOR |
| Background | It is a flavonoid that can activate SIRT1 and also inhibit PI3Kγ, PI3Kδ and PI3Kβ. ) |
| Biological Activity | Quercetin是一种天然黄酮类化合物，可激活或抑制许多蛋白质的活性。 槲皮素可激活SIRT1，也可抑制 PI3K，抑制PI3K γ，PI3K δ，PI3K β的 IC50 分别为2.4 μM, 3.0 μM, 5.4 μM。[1-3] |
| IC50 | PI3Kβ:5.4μM;PI3Kδ:2.4μM;PI3Kγ:3μM [1-3] |
| Data Literature Source | [1]. Navarro-Núez L，et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. [2]. Yu XB，et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81. [3]. Yang F，et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Yao X, Mei Y, Mao W. Evid Based Complement Alternat Med. 2021 Nov 27;20211386078.
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